What is the ETHYL THIAZOLE-4-CARBOXYLATE?

ETHYL THIAZOLE-4-CARBOXYLATE is Pale-yellow crystalline solid, while it's Molecular Formula is C6H7NO2S. Pale-yellow crystalline solid Ethyl 4-Thiazolecarboxylate (cas# 14527-43-6) is a compound useful in organic synthesis.

What is the CAS number for ETHYL THIAZOLE-4-CARBOXYLATE?

The CAS number of ETHYL THIAZOLE-4-CARBOXYLATE is 14527-43-6.

What is ETHYL THIAZOLE-4-CARBOXYLATE (14527-43-6) used for?

InChI:InChI=1/C6H7NO2S/c1-2-9-6(8)5-3-10-4-7-5/h3-4H,2H2,1H3

Product classification

14527-43-6

Product Name：ETHYL THIAZOLE-4-CARBOXYLATE
Molecular Formula：C₆H₇NO₂S
Purity：99%
Molecular Weight：157.193

Inquiry

Product Details;

CasNo： 14527-43-6

Molecular Formula： C₆H₇NO₂S

Appearance： Pale-yellow crystalline solid

High Quality High Purity 14527-43-6 Ethyl thiazole-4-carboxylate Global On Sale with Best Price

Molecular Formula:C6H7NO2S
Molecular Weight:157.193
Appearance/Colour:Pale-yellow crystalline solid
EC Number:800-336-5
DSSTox Substance:DTXSID90407423
Nikkaji Number:J1.835.748H
Wikidata:Q72477376
XLogP3-AA:1.5
Complexity:129
PSA：67.43000
Density:1.242 g/cm³
LogP:1.31980

ETHYL THIAZOLE-4-CARBOXYLATE(Cas 14527-43-6) Usage

Chemical Properties	Pale-Yellow Crystalline Solid
Uses	Ethyl thiazole-4-carboxylate (cas# 14527-43-6) is a compound useful in organic synthesis. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer.
Synthesis Reference(s)	Synthesis, p. 681, 1976 DOI: 10.1055/s-1976-24156

Isomeric SMILES: CCOC(=O)C1=CSC=N1

14527-43-6 Relevant articles

Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and-5

Akihito Dan, Takaaki Shiyama, Kazuto Yamazaki, Naoto Kusunose, Katsuya Fujita, Hideshi Sato, Kazutaka Matsui, Masafumi Kitano

, Bioorganic & Medicinal Chemistry Letters Volume 15, Issue 18, 15 September 2005, Pages 4085-4090

Protection of commercially available ethyl 2-amino-1,3-thiazole-4-carboxylate (II-1) with allyloxycarbonyl group and saponification with NaOH yield II-2.

Synthesis, crystal structure, Hirshfeld surface investigation and comparative DFT studies of ethyl 2-[2-(2-nitrobenzylidene) hydrazinyl] thiazole-4-carboxylate

Muhammad Haroon, Tashfeen Akhtar, Muhammad Yousuf, Muhammad Nawaz Tahir, Lubna Rasheed, Syeda Saniya Zahra, Ihsan ul Haq & Muhammad Ashfaq

, BMC Chemistry volume 16, Article number: 18 (2022)

The ethyl 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate (1), a thiazole ester, was synthesized by refluxing 1-(2-nitrobenzylidene)thiosemicarbazide and ethyl bromopyruvate.

Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors

Vladimir A. Ryabinin a, Olga D. Zakharova b, Ekaterina Y. Yurchenko b, Olga A. Timofeeva b, Igor V. Martyanov b, Andrei A. Tokarev a, Eugeny F. Belanov a, Nikolai I. Bormotov a, Laura Tarrago-Litvak c, Marie Line Andreola c, Simon Litvak c, Georgy A. Nevinsky b, Alexander N. Sinyakov a

, Bioorganic & Medicinal Chemistry Volume 8, Issue 5, May 2000, Pages 985-993

The Ethyl thiazole-4-carboxylate was selected as the starting material to obtain the target products. The amino group-protected 1-hydroxy-1,2,3-benzotriazole ester of 2-amino-1,3-thiazole-4-carboxylate was used as a synthon.

14527-43-6 Process route

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 14527-43-6
ethyl thiazole-4-carboxylate

: 73956-17-9
ethyl 2-formyl-1,3-thiazole-4-carboxylate

Conditions

Conditions	Yield
ethyl 2-methylthiazole-4-carboxylate; With selenium(IV) oxide; acetic acid; for 12h; Reflux; Inert atmosphere; With sodium hydrogencarbonate; In water;	55% 21%

: 3973-08-8
Thiazole-4-carboxylic acid

: 64-17-5
ethanol

: 14527-43-6
ethyl thiazole-4-carboxylate